Yingxin Chen
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Electroactive microneedle augmented stem cell therapy in myocardial infarction
Abstract Ischemic heart disease and related sequelae pose tremendous burdens on worldwide medical care. The excessive activation of cardiomyocytes and cardiac fibroblasts further exacerbates the prognosis after necrosis. Decades of stem cell therapy in preclinical studies suggested promising results in cardiomyocyte regeneration and tissue remodeling. However, few formulations achieved clinical translation due to the limited stem cell engraftment and insufficient arousal of resident cardiomyocytes.
Amniotic membrane transplantation combined with cryotherapy vs. lamellar keratoplasty for medically refractory peripheral ulcerative keratitis: a retrospective cohort study
Abstract Background: Medically refractory peripheral ulcerative keratitis (PUK) is a severe condition requiring urgent surgery. This study compares the clinical outcomes of amniotic membrane transplantation (AMT) combined with cryotherapy vs. lamellar keratoplasty (LKP) for this high-risk group. Methods: This retrospective cohort study evaluated patients with refractory PUK who underwent either AMT or LKP with a 12-month follow-up.
Comparison of Transplantation Outcomes of Human Cornea vs. Acellular Porcine Corneal Stroma in Noninfectious Peripheral Ulcerative Keratitis: A Single‐Center Retrospective Cohort Study
To compare the effectiveness and prognosis of lamellar keratoplasty (LK) using human cornea and acellular porcine corneal stroma (APCS) for noninfectious peripheral ulcerative keratitis (PUK). Fifty-eight patients with noninfectious PUK who underwent LK from 2013 to 2023 were included in this retrospective study. Patients were divided into human cornea (n = 27) and APCS (n = 31) groups according to corneal graft material.
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