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Correlating somatic copy number alteration in aqueous humour cfDNA with chemotherapy history, eye salvage and pathological features in retinoblastoma
Background This study determined to probe the potential association between somatic copy number alteration (SCNA) in retinoblastoma (RB) aqueous humour (AH) and pathological high-risk factors, clinical features and previous chemotherapy history. Methods Single-centre retrospective cohort study from including 58 AH samples collected from 58 patients diagnosed. Among them, 41 samples were collected after enucleation and 17 samples were collected before intravitreal chemotherapy.
Diffuse pattern, orbital invasion, perineural invasion and Ki-67 are associated with nodal metastasis in patients with eyelid sebaceous carcinoma
Discussion The study was the largest single-centre retrospective series of eyelid SC and provided detailed information on nodal metastasis.
Correlating somatic copy number alteration in aqueous humour cfDNA with chemotherapy history, eye salvage and pathological features in retinoblastoma
Yingxiu Luo1,2, Mingpeng Xu3, Ludi Yang1,2, Yiran Yao1,2, http://orcid.org/0000-0002-8907-9100Jesse L Berry4,5, Liya Xu5, Xuyang Wen1,2, Xiaoyu He1,2, Minglei Han1,2, Xianqun Fan2, http://orcid.org/0000-0001-7442-1391Jiayan Fan1,2, http://orcid.org/0000-0001-6642-7451Renbing Jia1,2 1Department of Ophthalmology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China 2Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology, Shanghai, China 3Department...
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