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Yingyi Cong

As seen in: Nature
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LRP8 is a functional receptor for yellow fever virus

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By Miao Mei, ZIHAN ZHANG, Yue Yin, Jiali Tan, Chao Yun Jiang, Yu Gao, Zhaoyang Wang, Donghong Wang, Zhiyuan Zhang, Yousong Peng, Wenjie Tan, Jiandong Li, Hanxuan Wang, Ren Lang, Qiang He, Zihou Deng, Xiaojie Huang, Bin Luo, Chao Shan, Yonghong Zhang, Lin Mei, Xu Tan, Yingyi Cong
| Nature Verified
Abstract Yellow fever virus (YFV) is an arbovirus causing substantial human morbidity and mortality. The live-attenuated 17D strain serves as vaccine and is one of the most successful vaccines so far. Receptor usage between attenuated and pathogenic YFV strains remains unclear. Here we performed a barcoded, genome-wide human open-reading frame library screen and identified LRP8 (also named APOER2) as a receptor for YFV.
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