Yingying Luo
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Landscape of the upper and lower airway microbiota in children with community-acquired pneumonia
ABSTRACT Community-acquired pneumonia (CAP) is one of the most common causes of death in children. Obtaining lower airway samples from children with CAP has so far remained challenging. This multicenter study enrolled 198 children with CAP indicated for fiberoptic bronchoscopy. Nasopharyngeal aspirates and bronchoalveolar lavage fluid (BALF) were collected for targeted next-generation sequencing (tNGS) and 16S ribosomal RNA (rRNA) sequencing to compare the pathogens and microbiota.
The association of positive and negative affect with care dependence in elderly patients with senile cataract: the mediating role of self-regulatory fatigue
Abstract Senile cataract is a leading cause of visual impairment in older adults worldwide, yet the psychological mechanisms (particularly the role of self-regulatory fatigue) through which affective states influence care dependence in this population remain poorly understood. A cross-sectional survey was conducted in the Ophthalmology Outpatient Department of the Affiliated Hospital of Guizhou Medical University from January to May 2025.
Association between homocysteine and severe cerebral small vessel disease burden in patients with type 2 diabetes mellitus
Highlights ● The study found that higher serum Hcy levels were associated with an increased burden of cerebral small vessel disease (CSVD) in individuals with type 2 diabetes mellitus. ● Subgroup analysis revealed that the link between Hcy and severe CSVD was particularly pronounced in patients with a lower BMI. ● The findings suggest that monitoring Hcy levels could help identify T2DM patients at higher risk of CSVD, especially those with lower BMI.
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