Yingying Meng
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Recent Progress in Organic Small‐Molecule Antibacterial Agents
Antibiotic resistance has become a critical global threat, creating an urgent need for new antibacterial agents. Among therapeutic modalities, small-molecule antibacterials offer significant advantages, including controllable metabolism and flexible structural design, making them an excellent platform for combating drug-resistant bacteria.
Light-triggered molecular mechanotherapy of tumor using membrane-mimicking conjugated oligoelectrolytes
Abstract A class of light-mediated mechanotherapeutic agents was developed on the basis of conjugated oligoelectrolytes (COEs), which mimic the topology of lipid membranes and intrinsically exhibit excellent biocompatibility. Low-dose white light irradiation (20 milliwatts per square centimeter for 10 minutes) substantially decreased the half-maximal inhibitory concentration of the optimized COE against A549 cancer cells from more than 256 to 0.6 micromolar.
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