Yingying Meng
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Therapeutic response to exclusive enteral nutrition correlates with suppressed IL-17 signaling activity and diminished IL-1β secretion in pediatric Crohn's disease
Abstract Background: To identify molecular correlates associated with therapeutic outcomes of exclusive enteral nutrition (EEN) in pediatric Crohn's disease (PCD). Methods: This prospective observational cohort study recruited 27 treatment-naive pediatric patients with endoscopically active PCD. Intestinal mucosal tissues were collected via endoscopy at baseline and after EEN treatment.
Recent Progress in Organic Small‐Molecule Antibacterial Agents
Antibiotic resistance has become a critical global threat, creating an urgent need for new antibacterial agents. Among therapeutic modalities, small-molecule antibacterials offer significant advantages, including controllable metabolism and flexible structural design, making them an excellent platform for combating drug-resistant bacteria.
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