Yingying Song
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NSUN2-mediated m5C modification of HIV-1 RNA enables evasion of RIG‑I‑dependent innate immunity
Discussion Our studies reveal a novel role of m5C modification in HIV-1 viral RNA to evade host innate immunity that supports efficient viral replication. A schematic model summarizing our findings is presented in Fig 7 Progeny HIV-1 from WT cells harbor m5C modification on their viral RNA; upon infecting target cells, these modifications prevent viral RNA from being recognized by RIG-I and enable evasion of the innate immune response.
The Wild Soybean C3HC4-Type RING Zinc-Finger Protein ZFP4 Enhances Resistance to Soybean Mosaic Virus
1 Introduction Soybean [Glycine max (L.) Merr.] is a legume crop that originated in China and is the largest source of edible vegetable oil and plant protein worldwide (Graham and Vance 2003). As the wild progenitor of cultivated soybean, wild soybean [Glycine soja Sieb.
HAMSIAA protects cyclophosphamide induced immunosuppression by modulating gut homeostasis and purine metabolism
Abstract Introduction: Dietary supplementation with functional starches serves as a promising intervention strategy for immune regulation, yet the immunomodulatory efficacy and underlying mechanisms of newly developed modified starch derivatives remain to be further explored. In this study, a cyclophosphamide (CTX) induced secondary immunodeficiency mouse model was adopted to investigate the immunoregulatory effects of indole 3 acetylated high amylose maize starch derivative (HAMSIAA).
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