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Yingyu Sun on Muck Rack

Yingyu Sun

As seen in: BioRxiv
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Articles

CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes

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By Nils M. Kronenberg, Yingyu Sun, Sidharth K. Sethi, Surjya N. Dash
| BioRxiv
Abstract Focal Segmental Glomerulosclerosis (FSGS) is a histologic lesion caused by a variety of injurious stimuli that lead to dysfunction/loss of glomerular visceral epithelial cells (i.e. podocytes). Pathogenic mutations in CRB2, encoding the type 1 transmembrane protein Crumb 2 Homolog Protein, have been shown to cause early-onset corticosteroid-resistant nephrotic syndrome (SRNS)/FSGS.
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