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Yingyue Pang on Muck Rack

Yingyue Pang

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Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad-Spectrum Antiviral Activity

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By Weilong Deng, Junyu Chen, Yingyue Pang
| Wiley Online Library Verified
1 Introduction Picornaviruses are a group of non-enveloped, single-stranded, positive-sense RNA viruses characterized by their small size (approximately 20–30 nm in diameter) and icosahedral capsid symmetry [1, 2]. These pathogens pose significant threats to human health: for instance, EV71-induced hand, foot, and mouth disease (HFMD) exhibits high transmissibility, predominantly affects pediatric populations, and may lead to severe neurological and cardiopulmonary complications.
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