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Yingyun Fu

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Articles

Single-cell multiomics uncovers an endothelial mechanosensitive PIEZO1-IL-33 axis driving pulmonary fibrosis

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By Lanlan Zhang, Ruijie Hou, Liping Jia, Shu Xia, Xin Zhang, Qian-Fang Meng, Qun Luo, Xing Tao Shi, Bingxin Guo, Ruifang Liang, Ludan Yue, Haizhao Xu, Pengbo Wang, Xia Tong, Lujie Liu, Lingwei Wang, Baicun Li, Zi Chen, Linfu Zhou, Rongchang Chen, Changbin Sun, Wei Xu, Lang Rao, Haibo Zhou, Bi-Sen Ding, Shanze Chen, Xuezhen Gui, Yingyun Fu, Linshu Zhang
| Nature Verified
Abstract Pulmonary fibrosis represents a progressive interstitial lung disease marked by excessive extracellular matrix deposition and architectural distortion. Vascular endothelial cells critically contribute to fibrogenesis through paracrine secretion of pro-fibrotic mediators, yet their mechanobiological regulation remains elusive.
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