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A critical review of systematic reviews and meta-analyses of curcumin for knee osteoarthritis
1 Introduction Knee osteoarthritis (KOA) is a chronic degenerative joint disorder that affects millions of individuals worldwide, particularly older adults. It is characterized by progressive cartilage degradation, subchondral bone changes, and synovial inflammation, leading to pain, stiffness, and functional impairment (Laslett et al., 2024). The condition not only diminishes quality of life but also imposes a significant economic and healthcare burden.
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