Yingzhu Li

Abstract Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-driven malignancy, making the viral protein EBNA1 a pivotal therapeutic target. This study evaluates VK-2019, a clinical-stage EBNA1 inhibitor, for its potential to sensitize NPC cells to chemotherapy. We report that VK-2019 synergistically enhances gemcitabine efficacy, reducing the IC50 by nearly 30-fold in EBV-positive C666-1 cells.

Abstract Countries differ in their energy infrastructures, economic structures, and socioeconomic contexts, resulting in uneven vulnerability to the energy transition. Advancing a just global transition requires that the most vulnerable are not left behind and that all countries make measurable progress. To support this effort, we introduce the Energy Transition Vulnerability Index (ETVI), a global metric assessing national-level vulnerability.

Abstract High myopia can lead to cataract, glaucoma, retinal detachment, choroidal neovascularisation, and macular degeneration, causing irreversible vision loss. Imaging detects these complications, but population screening is limited by equipment, and specialist availability. Here we show that a machine learning model using routine blood test results identifies people at increased risk of complications related to high myopia during standard health examinations.