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Decoding the human gut bacterial plasmids in colorectal cancer
Abstract Gut plasmids show heightened sensitivity to gut microenvironmental changes compared to their bacterial hosts. To explore their significance in colorectal cancer (CRC), we analyzed metagenomic data from 863 participants (312 CRC, 387 high-risk, 164 low-risk). Plasmid and bacterial profiles were characterized, along with trace elements and metabolites.
Aging characteristics of colorectal cancer based on gut microbiota
Abstract Background Aging is one of the factors leading to cancer. Gut microbiota is related to aging and colorectal cancer (CRC). Methods A total of 11 metagenomic data sets related to CRC were collected from the R package curated Metagenomic Data. After batch effect correction, healthy individuals and CRC samples were divided into three age groups. Ggplot2 and Microbiota Process packages were used for visual description of species composition and PCA in healthy individuals and CRC samples.
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Introduction. Differences in gut bacteria that are associated with the occurrence and development of colorectal cancer (CRC) exist between sexes and males have a higher morbidity of CRC. Gap Statement. Clinical data for the relationship between gut bacteria and sexes in patients with CRC are not available and are needed to support individualized screening and treatment programmes. Aim. To analyse the relationship between gut bacteria and sexes in patients with CRC. Methodology.
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