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FTO-mediated m6A modification alleviates diabetic nephropathy progression by downregulating the CYP2J3/Smurf2 axis
Abstract The m6A demethylase FTO is implicated in epigenetic regulation, yet its specific mechanism in diabetic nephropathy (DN) remains unclear. This study investigates whether FTO mitigates DN progression by regulating the CYP2J3/Smurf2 axis. Mouse glomerular mesangial SV40-MES-13 cells were treated with high glucose (HG). Gene and protein expressions were assessed via qPCR and Western blot. MeRIP-qPCR and RIP assays evaluated m6A modifications and FTO-CYP2J3 mRNA binding.
Computer Science > Computer Vision and Pattern Recognition
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