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Yinhao Zhou on Muck Rack

Yinhao Zhou

As seen in: Nature
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Articles

Structural insights into the MLH1–FAN1 interaction reveal an uncharacterized binding interface on MLH1

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By Yichang Chen, Haiyun Hu Verified, Xinci Shang, Keri M. Fishwick, Qin Xiao, Qiuyan Huang, Tao Jiang, Xiaolei Huang, Guanghui Wang, Xuechu Zhen, Guoqiang Xu, Su Qin, Alessandro Sartori, Yanli Liu, Giada Greco, Yinhao Zhou
| Nature Verified
Abstract Huntington’s disease is driven by CAG repeat expansion in the mutant huntingtin gene. Nuclease FAN1 and mismatch repair protein MLH1 regulate repeat expansion through direct interaction, but the underlying structural basis remains unclear. Here, we show that the MLH1 C-terminal domain binds to FAN1-derived peptides containing either the MIP or MIM motif with comparable affinities.
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