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Yinhong Chen

As seen in: Frontiers
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Articles

Transcriptomics-based analysis of muscle injury mechanism mediated by inflammatory imbalance in the Duchenne muscular dystrophy muscle microenvironment

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By Chunhui Shan, Yu Li, Nan Li, Zhe Zhao, Qi Bing, Yinhong Chen
| Frontiers
Abstract Background: Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disease characterized by progressive myofiber injury, chronic inflammatory response, and persistent fibrotic remodeling, for which no universal clinical treatment is currently available. The inflammatory-fibrotic microenvironment is regarded as a critical driver of DMD progression; nevertheless, the key molecules governing extracellular matrix (ECM) remodeling and immune imbalance remain incompletely elucidated.
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