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Dabrafenib plus trametinib in an elderly patient with BRAF V600E-mutant advanced pancreatic adenocarcinoma: A case report
Introduction Pancreatic adenocarcinoma (PAC) represents 90% of all pancreatic cancers and is aggressive with a poor prognosis (1). It is estimated to become the second leading cause of cancer-related death in the United States by 2030, with a 5-year survival rate of about 10% (2, 3). Since the pancreas is located in the retroperitoneum, the disease often manifests insidiously with nonspecific symptoms. Most patients diagnosed at advanced stages are unable to undergo surgical resection (4).
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