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The Role of Sex Steroid Hormones in the Association Between Manganese Exposure and Bone Mineral Density: National Health and Nutrition Examination Survey 2013-2018
1. Introduction Osteoporosis is a disease characterized by decreased bone mineral density (BMD), compromised bone architecture, and an increased risk of fracture [1]. According to the World Health Organization (WHO), osteopenia is defined as a BMD value measured by dual-energy X-ray absorptiometry (DXA) that is 1 to 2.5 standard deviations below the mean of a healthy, sex-matched population.
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