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A Multi‐Domain Space‐Time Spectral Collocation Method for the Huxley Equation
A multi-domain space-time spectral collocation scheme is proposed for the mixed problem of the Huxley equation, utilizing Legendre–Gauss–Lobatto nodes as interpolation points. The Huxley equation is transformed into a system of nonlinear matrix equations, with the numerical solution obtained through fixed-point iteration. A novel composite quasi-orthogonal approximation is introduced.
Tissue and Cell Dual‐Penetrating Dendritic Lipopeptide Liposomes for Hypertrophic Scar Treatment
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202313036-sup-0001-SuppMat.pdf2.8 MB Supporting Information References 1a) , , , , , , , , , , , , , Nat. Commun. 2021, 12, 6242; b) , , , , , , , , , , , , , , , , , , Science 2021, 372, 362; c) , , , , , , , , , , , , , , , , , , , , , , , , , , , Sci. Transl. Med. 2021, 13, eabb3312. 2a) , , , , , , , , ACS Appl. Mater.
The nonopioid cholinergic agonist GTS-21 mitigates morphine-induced aggravation of burn injury pain together with inhibition of spinal microglia activation in young rats
Repetitive opioid use does not always alleviate basal pain, procedural pain, or both after burn injury. Mitigation of burn injury-site pain can be achieved by GTS-21 stimulation of α7-acetylcholine nicotinic receptors (α7AChRs) and reduced microglia activation in rat. We tested the hypothesis that morphine exaggerates burn injury-site pain and GTS-21 alleviates both morphine-induced aggravated burn injury pain and microglia activation.
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