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Yini Shang on Muck Rack

Yini Shang

As seen in: Wiley Online Library
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Articles

Single-Cell Computational Frameworks for Quantifying BET Bromodomain Inhibitor Resistance and Screening Re-Sensitizer Drugs in Triple-Negative Breast Cancer

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By Haizhou Liu, Mengqin Yuan, Yini Shang
| Wiley Online Library Verified
1 Introduction Triple-negative breast cancer (TNBC), which accounts for approximately 15%–20% of all breast cancer patients, is the most aggressive subtype. Currently, chemotherapy is one of the most common treatments for TNBC [1, 2]. Unfortunately, 60% to 70% of TNBC patients do not exhibit a favorable response to chemotherapy [2]. BET bromodomain inhibitor (BBDI) is regarded as a potentially novel candidate to treat TNBC in preclinical experiments [3].
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Tetrastigma Hemsleyanum Polysaccharide Suppresses Triple-Negative Breast Cancer by Disrupting the Hippo-YAP/TEAD4-PDIA4 Axis and Endoplasmic Reticulum Stress Adaptation

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By Wentao Si, Youxue Zhang, Yini Shang
| Wiley Online Library Verified
1 Introduction Triple-negative breast cancer (TNBC) accounts for 15%–20% of all breast cancers yet is responsible for a disproportionate share of the ∼500 000 annual breast-cancer deaths worldwide [1, 2]. Its aggressive metastatic behavior—driven by a complex network of signaling pathways enhancing cell migration, invasion, and therapy resistance—remains the major cause of treatment failure and poor survival outcomes [3].
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