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LMOD2 attenuates Ang II-induced cardiomyocyte hypertrophy by activating the Nrf2-mediated antioxidant pathway
Abstract Pathological cardiac hypertrophy constitutes a common pathway in heart failure progression. Although previous studies have identified LMOD2 as a protective factor against dilated cardiomyopathy, its functional role and mechanistic involvement in pathological hypertrophy remain elusive. Here our study demonstrates that LMOD2 expression is significantly downregulated in angiotensin II (Ang II)-induced H9c2 cardiomyocyte hypertrophy.
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