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Volume 214 Issue Supplement_1
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Anti-CD137 Agonist Antibody-Independent and Clinically Feasible Preparation of Tumor-Infiltrating Lymphocytes From Soft Tissue Sarcoma and Osteosarcoma
Abstract Background: Tumor infiltrating lymphocytes (TILs) therapy has been proved for treatment of metastatic melanoma and is under investigation for other types of solid tumors. However, these successes are threatened by discontinued supply of GMP-grade anti-CD137 agonist, a key TIL preparation reagent. Therefore, exploring a GMP-adherent method for expanding endogenous TILs without anti-CD137 agonist is urgent.
PVAT-conditioned media from Dahl S rats on high fat diet promotes inflammatory cytokine secretion by activated T cells prior to the development of hypertension
Citation: Jin Y, Liu S, Guzmán KE, Kumar RK, Kaiser LM, Garver H, et al. (2024) PVAT-conditioned media from Dahl S rats on high fat diet promotes inflammatory cytokine secretion by activated T cells prior to the development of hypertension. PLoS ONE 19(10): e0302503. https://doi.org/10.1371/journal.pone.0302503 Editor: Junpeng Wang, Henan University, CHINA Received: February 9, 2023; Accepted: April 7, 2024; Published: October 3, 2024 Copyright: © 2024 Jin et al.
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