Yining Liu
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TABF as a Double Proton Sponge: Steric Preorganization versus Antiaromatic Destabilization Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Proton sponges are a distinctive class of highly basic organic molecules whose basicity is governed by molecular architecture. We report the synthesis of a proton sponge scaffold, 1,1′,8,8′-tetraazabifluorenylidene (TABF), based on a bifluorenylidene backbone incorporating pyridine units and capable of binding two protons intramolecularly.
A Song Sung Blue
Film A Song Sung Blue menghadirkan kisah coming-of-age yang emosional tentang Liu Xian, remaja 15 tahun yang harus menjalani musim panas paling sepi dalam hidupnya. Setelah sang ibu berangkat ke Afrika untuk bekerja sebagai dokter, Liu Xian tinggal bersama ayahnya yang sudah lama berpisah dari ibunya. Perubahan besar itu membuat Liu Xian merasa sendirian dan seperti anak yang terlupakan di tengah keluarganya sendiri.
Nucleolar migration regulates meiotic sex chromosome inactivation via phase separation during mammalian spermatogenesis
Abstract During spermatogenesis, the unsynapsed XY chromosomes undergo meiotic sex chromosome inactivation (MSCI) and form a heterochromatic XY body. Defects in MSCI lead to meiotic arrest and male infertility. Although DNA damage response (DDR) factors are established as key initiators of MSCI, how transcriptional silencing is subsequently achieved remains elusive. Here, we identify the nucleolar components NPM1, SENP3, and rRNA as essential downstream effectors of DDR signaling in MSCI.
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