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Yining Zhang on Muck Rack

Yining Zhang

As seen in: Color Research & Application, Nature, Wiley Online Library, Frontiers, MDPI, Taylor & Francis Online, ACS Publications, British Journal of Ophthalmology, Royal Society of Chemistry, American Physical Society and
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Articles

Genome-wide CRISPR screen identifies mutation-specific pathways converging on TAZ/TEAD activation in mutant p53-driven breast cancer

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By Lilian Nwachukwu, Anasuya Chattopadhyay Pal, Yining Zhang, Lydia Sakala, Chenxi Xu, Joshua LaBaer, Jin Gyoon Park
| Nature Verified
Abstract Most clinical mutations of TP53 are missense mutations. We previously showed that TP53-missense mutations common in triple-negative breast cancer (TNBC) patients produce neomorphic phenotypes compared to TP53-null cells, with the TAZ/TEAD pathway strongly associated with cell invasion in aggressive p53 mutants. But TP53 mutations alone are insufficient for full oncogenesis. We performed a genome-wide CRISPR screen to identify "co-drivers" of the weakly aggressive p53 mutation, Y234C.
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A netnographic study of translanguaging in multilingual game localisation

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By Rui Zhang, Yining Zhang
| Dialnet - Universidad de La Rioja
Game localisation has emerged as a distinct academic field, driven by the global expansion of the gaming industry. It shares common features with audiovisual translation, including intralinguistic, interlinguistic, and intersemiotic dimensions (Wang, Wang, and Lin. 2024. “‘There are no restrictions on me’: a netnographic approach to amateur subtitling from the perspective of translanguaging’.
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Precision targeting of tumor-associated macrophages via a 6-substituted pyrrolo[2,3- d ]pyrimidine chimeric molecule for enhanced cancer immunotherapy

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By Yining Zhang, Binghao Guo, Lixiao Guo, Yuqing Wang, Yuwei Zheng, Mengqi Wu, Xueyu Yao, Zeshi Li, Huaying Liu, Zixuan Wang, Mengyuan Lian, Xiaowei Shi, Xin Li Verified, Yi Liu, Zenghui Sun, Haitao Yang, Lei Wang, Ruijuan Xing
| Nature Verified
Abstract Small-molecule PI3Kγ inhibitors can reprogram immunosuppressive myeloid cells but are limited by rapid clearance, lack of cell-type selectivity, and systemic exposure to non-target tissues. Here, we extended a previously developed folate receptor (FR)-directed 6-substituted pyrrolo[2,3-d]pyrimidine ligand to the intracellular delivery of AS-252424.
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