Yining Zheng

1 Introduction The gut barrier serves as the primary defense mechanism separating the gut from the external environment.

BHB-CoA β-hydroxybutyryl-CoA lithium salt BHB β-hydroxybutyrate FBP1 fructose 1,6-bisphosphatase 1 G6PC glucose-6-phosphatase HDACs histone deacetylase Kbhb β-hydroxybutyrylation LC-MS/MS liquid chromatography mass spectrometry MCT1 monocarboxylate transporter 1 NAM nicotinamide NEB negative energy balance NEFAs nonesterified fatty acids p300 histone acetyltransferase p300 PBS phosphate-buffered saline PCK1 phosphoenolpyruvate carboxykinase 1 PMSF phenylmethanesulfonyl fluoride TSA...

1 Introduction Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, represents a globally recognized condition characterized by chronic immune-mediated intestinal inflammation.[1] The etiology of IBD is multifactorial, with a confluence of genetic predisposition, dietary habits, and antibiotic usage being significant contributors.[2] Over the years, alterations in the gut microbiota have been implicated in the onset of chronic intestinal inflammation.[3] In...