Yining Zhu
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N 4 -Acetylcytidine enhances synthetic mRNA translation yield and fidelity
Abstract Synthetic mRNA therapeutics offer a versatile platform for treating diverse conditions, including cancer and infectious diseases. For delivery into cells, these mRNAs are encapsulated in lipid nanoparticles and commonly incorporate modified ribonucleotides to improve stability, enhance translation and mitigate immune recognition1.
Computer Science > Computer Vision and Pattern Recognition
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Triplet Energy Transfer-Mediated Intermolecular Paternò-Büchi Reaction for the Synthesis of Trifluoromethylated Oxetanes | Organic Letters
Oxetanes have emerged as compact, polar, and conformationally well-defined motifs that serve as (bio)isosteres of both gem-dimethyl groups and carbonyl derivatives in medicinal chemistry. (1) Unlike flat carbonyls, the oxetane ring deviates from planarity, enhancing three-dimensionality, conformational rigidity, and vector diversity within small-molecule scaffolds (Figure 1A).
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