Skip To Main Content
Yinjie Yang on Muck Rack

Yinjie Yang

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Yinjie

Contact Yinjie, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Mutant calreticulin interacts with MPL in the secretion pathway for activation on the cell surface

|
By Marito Araki, Masato Koike, Yinjie Yang, Nami Masubuchi
| Nature Verified
Abstract Studies have shown that mutant calreticulin (CALR) constitutively activates the thrombopoietin (TPO) receptor MPL and thus plays a causal role in the development of myeloproliferative neoplasms (MPNs). To further elucidate the molecular mechanism by which mutant CALR promotes MPN development, we studied the subcellular localization of mutant CALR and its importance for the oncogenic properties of mutant CALR.
Open in Who Shared Issue with article?

Homomultimerization of mutant calreticulin is a prerequisite for MPL binding and activation

|
By Marito Araki, Yinjie Yang, Misa Imai, Yoshihisa Mizukami
| Nature Verified
Studies have previously shown that mutant calreticulin (CALR), found in a subset of patients with myeloproliferative neoplasms (MPNs), interacts with and subsequently promotes the activation of the thrombopoietin receptor (MPL). However, the molecular mechanism behind the activity of mutant CALR remains unknown. Here we show that mutant, but not wild-type, CALR interacts to form a homomultimeric complex.
Open in Who Shared Issue with article?
See all 2 articles