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Optimization of Immunotherapy Strategies Based on Spatiotemporal Heterogeneity of Tumour‐Associated Tissue‐Resident Memory T Cells
1 Introduction Tissue-resident memory T cells (TRMs) were first identified in 2009 as a special subgroup of memory T cells that do not enter the circulation but reside in the skin, providing immune protection against local infection [1]. Since then, TRMs have been found to exist widely in the skin, lung, reproductive tract, gastrointestinal tract, and other tissues, and have a strong immune protection against local inflammation or tumours [2-4].
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