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Yinmo Yang

As seen in: Nature, MDPI
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Articles

Chemotherapy-induced senescence promotes stroma stiffness and antioxidant adaptation to promote chemoresistance in pancreatic ductal adenocarcinoma

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By Xinxin Liu, Zhihua Huang, Bohan Yang, Yimeng Du, Yixin Sun, Enkui Zhang, Xiaofeng Kang, Chunyuan Xue, Kai Chen, Yongsu Ma, Xiaodong Tian, Xiaojie Xu, Yinmo Yang
| Nature Verified
Abstract Chemoresistance in pancreatic ductal adenocarcinoma (PDAC) is partly driven by pathological stromal remodeling, yet the underlying mechanisms remain poorly understood. Here, we show that gemcitabine treatment induces tumor cell senescence and activates cancer-associated fibroblasts via the senescence-associated secretory phenotype, leading to progressive fibrotic matrix stiffening.
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Nab-paclitaxel plus S-1 induction chemotherapy for patients with locally advanced pancreatic cancer: a multicenter, open-label phase 2 study

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By Zhe M. Cao, Wenhao Luo, Juan Li, Hao Chen, Yueze Liu, Shengmian Li, Yinmo Yang, Yuejuan Cheng, Taiping Zhang, Huadan Xue, Chunmei Bai, Yupei Zhao, Jiangdong Qiu
| Nature Verified
Abstract Locally advanced pancreatic cancer (LAPC) is associated with a poor prognosis and limited therapeutic options. This study aimed to evaluate the efficacy and safety of nab-paclitaxel plus S-1 (SnP) as a first-line treatment in patients with previously untreated LAPC.
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Crosstalk between Pancreatic Cancer Cells and Cancer-Associated Fibroblasts in the Tumor Microenvironment Mediated by Exosomal MicroRNAs

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By Xiaodong Tian, Xiangyu Chu, Yinmo Yang
| MDPI
1. Introduction The incidence and associated mortality of pancreatic ductal adenocarcinoma (PDAC) are still steadily increasing, which is mainly due to its extremely poor prognosis. Cancer-related mortality of this dismal disease ranks seventh globally and is sixth in China [1,2]. Because of the insidious onset and the unspecific clinical manifestations, it is difficult to diagnose PDAC at an early stage; hence, only 20% of patients are amenable to surgical treatment [3].
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