Yinpeng Wang

Abstract The substitution of classical dienes with C–C bonds in Diels–Alder-type reactions is a compelling paradigm in modern syntheses. Although activation of C–C bonds α to a single heteroatom has been well established, extending this strategy to synthetically valuable C–C moieties α to two heteroatoms remains challenging because of the competing activation of adjacent C–heteroatom bonds.

1 Introduction Fluorine-containing compounds have become essential in fields such as medicine and materials science, thanks to their unique ability to enhance key properties such as lipophilicity, acidity, bioavailability, and metabolic stability [1-4]. Fluorinated groups can also act as bioisosteres, mimicking other functional groups while improving molecular performance [5].