Yinqi Wu

1 Introduction The oxidation of cyclohexane to cyclohexanol/cyclohexanone [known as ketone-alcohol oil (KA-oil)] is an industrially important reaction as it is the main route for the production of ϵ-caprolactone, ϵ-caprolactam, and adipic acid, which are heavily used in the polymer industry as feed stocks for nylon 6 and nylon 6,6.1, 2 Chemical routes for the transformation of cyclohexane to KA-oil demand relatively harsh conditions of temperature and/or pressure,3, 4 thereby increasing the...

The Front Cover shows enzymatic cascades for the valorisation of fatty acids with peroxygenase-catalysed hydroxylation as key step. Functionalisation of fatty acids generally relies on pre-existing functional groups such as C=C-double bonds. In their Research Article, F. Hollmann and co-workers demonstrated the synthetic potential of a peroxygenase mutant AaeUPO for selective fatty acid oxyfunctionalisation.

Graphical Abstract Multi-enzyme cascade: Peroxygenases enable facile functionalisation of fatty acids. The resulting hydroxy fatty acids can be further derivatised to new building blocks for chemical synthesis. Abstract Utilisation of fatty acids generally relies on pre-existing functional groups such as the carboxylate group or C=C-double bonds. Addition of new functionalities into the hydrocarbon part opens up new possibilities for fatty acid valorisation.