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Yinquan Fang on Muck Rack

Yinquan Fang

As seen in: Nature
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Articles

Complement receptor 3 (CR3)-dependent microglial synapse elimination drives Parkinson’s disease pathogenesis in systemic inflammation

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By Lei Cai, Yihe Zhang, JiaYi Li, Lamei Hu, Qinghao Meng, Jingyi Shao, Haotian Deng, Yiying Liu, Jiaqi Liu, Yue Liang, Nanshan Song, Jianhua Ding, Yi Fan, Ming Lu, Gang Hu, Yinquan Fang
| Nature Verified
Abstract Although systemic inflammation has been implicated in PD pathogenesis, the underlying mechanisms remain poorly understood. In this study, we investigate the pathological events in a systemic inflammation-induced PD mouse model. We demonstrate that synaptic loss in the midbrain occurs as early as 1 day after the final lipopolysaccharide (LPS) administration, preceding dopaminergic (DA) neuron degeneration, which was observed only at later stages (14 days).
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