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Yinquan Huang on Muck Rack

Yinquan Huang

As seen in: Nature
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Articles

Rational design of carbazole-based STING inhibitors for treating cGAS-STING pathway-driven inflammatory disorders

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By Hui Li, Wei Zheng, Mei Li, Zhidan Fan, Ziwen Feng, Xiaoyan Liu, Shiduo Zhang, Haohao Lu, Yifan Zhang, Linlin Li, Haiguo Yu, Yibei Xiao, Qidong You, Xiaoli Xu, Wenjing Bian, Yinquan Huang, Jiaqing Jia, Chunchen Che
| Nature Verified
Abstract Stimulator of Interferon Genes (STING) is a pivotal adaptor protein in the innate immune pathway, and its aberrant activation is closely associated with the pathogenesis of autoimmune diseases. Although it has emerged as an attractive therapeutic target for inflammatory disorders, current STING inhibitors still face challenges including off-target toxicity and limited understanding of binding mechanism.
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