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Yinshan Chen

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As seen in: ACS Publications
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Articles

Effect of Buffer pH and Concentration on the Dissolution Rates of Sodium Indomethacin-Copovidone and Indomethacin-Copovidone Amorphous Solid Dispersions | Molecular Pharmaceutics

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By Shijia Tang, Chen Mao, Yinshan Chen, Cheng W. Chiang
| dx.doi.org
Download Hi-Res ImageDownload to MS-PowerPointCite This:Mol. Pharmaceutics 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
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Effect of Counterions on Dissolution of Amorphous Solid Dispersions Studied by Surface Area Normalized Dissolution

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By Joseph W. Lubach, Shijia Tang, Ajit S. Narang, Yinshan Chen
| ACS Publications
Solubility enhancement has become a common requirement for formulation development to deliver poorly water soluble drugs. Amorphous solid dispersions (ASDs) and salt formation have been two successful strategies, yet there are opportunities for further development. For ASDs, drug–polymer phase separation may occur at high drug loadings during dissolution, limiting the increase of drug loadings in ASD formulations.
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