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Yinshan Wu on Muck Rack

Yinshan Wu

As seen in: Nature
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Articles

CYP1B1-mediated metabolic reprogramming drives immune dysregulation in sepsis: a single-cell transcriptomic and therapeutic exploration

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By Yinshan Wu, Yunkun Lu, Lijun Du, Xiuliu Guo, Donghai Wang, Hong Yu, Jinyan Xie, Feng Guo
| Nature Verified
Abstract Sepsis, a life-threatening condition characterized by dysregulated immune responses, poses significant clinical challenges due to high mortality and limited therapeutic strategies. Emerging evidence highlights immune-metabolic dysregulation, particularly in monocytes and macrophages, as a critical driver of sepsis pathogenesis.
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Association between baseline pulse pressure and prognosis in critically ill patients: a retrospective cohort study

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By Yifan Gao, Wei Su, Ying Chen, Senbin Hu, Weipeng Huang, Jiali Mao, Minmin Chen, Shu Cao, Feng Guo, Yinshan Wu, Zhendong Fang, Kedi Gao, Qixun Luo
| Nature Verified
Abstract To investigate the association between baseline pulse pressure (PP) and mortality in critically ill patients. This cohort study analyzed 22,035 ICU patients from the MIMIC-IV database. Baseline PP was defined as the first recorded value after admission. Outcomes included in-hospital, 180-day, and 365-day all-cause mortality. Feature importance was assessed using XGBoost. The relationship between PP and mortality was modeled with smooth curve fitting and threshold analysis.
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