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Yinshui Miao on Muck Rack

Yinshui Miao

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Articles

4-Hydroxytamoxifen suppresses the malignant progression of lung adenocarcinoma by inhibiting MAPK signaling pathway

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By Hui Yang, Zhaojun Li, Hanyan Xu, Jinli He, Ping Zhang, Yunyun Liu, Shengsong Chen, Qingyuan Zhan, Xingqian Wang, Yinshui Miao, Feizhou Xu
| Nature Verified
Abstract Lung adenocarcinoma (LUAD) has poor clinical outcomes due to limited therapeutic options and drug resistance. Here, 4-hydroxytamoxifen (4-OHT) was identified as a potential anti-tumor agent through drug repurposing screening of a human endogenous metabolite library. 4-OHT inhibited proliferation of A549 and PC9 cells, suppressed cell migration, reversed epithelial-mesenchymal transition (EMT), and induced apoptosis.
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