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Yinteng Chu on Muck Rack

Yinteng Chu

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Articles

Sphingosine-1-Phosphate-derived 2-Hexadecenal is a central mediator of ocular neovascularization by inhibiting Sphingosine-1-Phosphate receptor 5

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By Xin Qian, Rui Ge, Tian Kuang, Xin Zhang, Katrin Bennewitz, Bowen Lou, Weijie Hao, Volker Ast, Glynis Klinke, Gernot Poschet, Jakob Morgenstern, Thomas Fleming, Ingrid Hausser, Julia Szendroedi, Peter Nawroth, Jens Kroll, Yinteng Chu
| Nature Verified
Abstract Sphingosine-1-phosphate (S1P) is a crucial sphingolipid mediator in vasculature and neovascular eye diseases by controlling angiogenesis, inflammation and fibrosis. Five S1P receptors (S1PRs) are key therapeutic targets, with several S1PR-targeted drugs already in clinical use or trials. However, the vascular function of its major metabolic product, the reactive lipid aldehyde 2-hexadecenal (2-HD), remains unexplored.
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