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Yinuo Cui on Muck Rack

Yinuo Cui

As seen in: Nature
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Articles

Structural insight into IscB’s RNA-lid-based inactivation mechanism

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By Ruochen Guo, Senfeng Zhang, Junlan Wang, Tao Hu, Kunming Liu, Qi Wang, Yao Liu, Ki Hyun Nam, Ziqing Winston Zhao, Quanquan Ji, Xin Xu, Ercheng Wang, Youyuan Zhu, Yao Yang, Min Luo, Peixiang Ma, Chunlong Xu, Chunyi Hu, Feizuo Wang, Yinuo Cui, Shengsheng Ma
| Nature Verified
Abstract IscB, a compact Cas9 ancestor from the obligate mobile element guided activity system, has attracted growing interest as a programmable genome editor because of its small size and therapeutic delivery potential. Despite its promise, structural insights into IscB’s regulation remain limited, with only a target-bound R-loop structure previously reported. Here, we present the structural trajectory of an engineered IscB, capturing its transition from a resting state to activation.
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