Yinuo Wang
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One-Pot Sequential Catalysis as a General Method for Pore-Wall Functionalization of Vinylene-Linked Covalent Organic Frameworks
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description anie75108-sup-0001-SuppMat.docx106.8 MB Experimental details and analysis are given in the Supporting Information of this article.
SETDB1 cooperates with the CRL4B complex to promote colorectal cancer tumorigenesis by disrupting circadian rhythm
Abstract The circadian rhythm is an intrinsic, self-regulatory physiological system in organisms that is hierarchically governed by core clock genes. Dysregulation of this rhythm is closely associated with tumor progression. However, the specific molecular mechanisms underlying circadian rhythm disruption–mediated colorectal cancer (CRC) remain largely elusive.
Alternative tandem transcription initiation links noncoding variants to human disease through translational control
Abstract Alternative tandem transcription initiation is a pervasive mechanism of gene regulation, yet its genetic impact on human disease remains largely unknown. Here, we systematically quantify the genetic regulation of alternative tandem transcription initiation across 25,859 samples from 49 normal human tissues and 33 tumor tissues.
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