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Yinuo Wang on Muck Rack

Yinuo Wang

As seen in: Nature, Wiley Online Library, arXiv, Frontiers, Frontiers in Immunology, Frontiers in Public Health, MDPI, ACS Publications, BMC Genomics, Royal Society of Chemistry and
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Articles

Alternative tandem transcription initiation links noncoding variants to human disease through translational control

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By Xudong Zou, Wei Wang, Yinuo Wang, Hui Chen, Xing Li, Shuxin Chen, Yangcan Li, Qin Li, Chen Hong Yu, Lei Li, Feihong Weng
| Nature Verified
Abstract Alternative tandem transcription initiation is a pervasive mechanism of gene regulation, yet its genetic impact on human disease remains largely unknown. Here, we systematically quantify the genetic regulation of alternative tandem transcription initiation across 25,859 samples from 49 normal human tissues and 33 tumor tissues.
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Enhanced antitumor immunity of mRNA vaccines by bioorthogonal-like delayed activation of exogeneous STING

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By Qiushi Qin, yanyun Hao, Ming Liu Verified, Yijia Li, Yunxuan Liu, Tao Ma, weixue Wang, Yu Hou, Ruochuan Liu, Yajuan Wang, Buyao Li, Xiaorong Guo, Kun Wang, Zhiqiang Zhao, Baocai Xing, Bin Ma, Bin Guo Ma, Yinuo Wang, Ning Zhang, Chuanhui Han, Lei Miao, Pengxia Qin, Ziqiong Jiang, Pengting Zhang
| Nature Verified
Abstract The development of cGAS–STING (stimulator of interferon genes) agonists as mRNA vaccine adjuvants has been hampered by widespread STING expression and by the observation that codelivered STING agonists suppress antigen mRNA translation. Here, to address these challenges, we engineer synchronized STING (Syn-STING): a lipid nanoparticle (LNP) codelivering antigen mRNA, mRNA encoding full-length STING transmembrane protein and a bioorthogonal-like delayed-release STING activator, DMXAA.
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The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing

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By Yinuo Wang, Gergana Dobreva
| Nature Verified
Abstract The nucleus is a highly organized and dynamic organelle, with hierarchical layers ranging from nucleosome positioning to chromatin domains and higher-order 3D genome topology. Viewed over time as the 4D nucleome, this organization enables precise and context-dependent transcriptional control.
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