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Yinxi Zou

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Articles

APOE4 and cognition in intracranial atherosclerosis: beyond Alzheimer's pathology

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By Anqi Cheng, Linwen Liu, Hebo Wang, Yinxi Zou
| Wiley Online Library Verified
1 BACKGROUND Intracranial atherosclerosis (ICAS) is increasingly recognized as an important contributor to cognitive impairment and dementia.1 Population-based studies indicate that ICAS affects 35% to 45% of older individuals and is independently associated with approximately 50% increased dementia incidence.2 Despite this substantial public health impact, the pathophysiological mechanisms linking ICAS to cognitive decline remain unclear.
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