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Yinxing Zhu on Muck Rack

Yinxing Zhu

As seen in: Nature, Science Magazine, Canadian Journal of Infectious Diseases & Medical Microbiology, Dove Medical Press
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Articles

Prefoldin complex promotes interferon-stimulated gene expression and is inhibited by rotavirus VP3 - Nature Communications

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By Yinxing Zhu, Dilip Kumar, Peter Jackson
| Nature Verified
Abstract Timely induction of interferons and interferon-stimulated genes (ISGs) is critical for successful host defense against viral infections. VP3 encoded by rotavirus is implicated in interferon antagonism. However, the precise mechanisms remain incompletely understood. By conducting tandem-affinity purification coupled with high-resolution mass spectrometry, we identify the prefoldin complex as the top cellular binding partner of VP3.
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SAMD9 senses cytosolic double-stranded nucleic acids in epithelial and mesenchymal cells to induce antiviral immunity - Nature Communications

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By Lili Ren, Yinxing Zhu, Dian Li, Danica M. Sutherland, Jia Liu, L. David Sibley
| Nature Verified
Abstract Sensing of cytosolic, double-stranded (ds) DNA or dsRNA molecules derived from microbial or endogenous sources triggers cell-intrinsic innate immunity, but sensors recognizing both cytosolic dsDNA and dsRNA are sparsely reported. Here we find that full-length human SAMD9 protein directly binds to synthetic or viral dsDNA or dsRNA. Overexpression of SAMD9 from various vertebrate species leads to robust production of interferons and pro-inflammatory cytokines.
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Photo-thermally controllable tumor metabolic modulation to assist T ce

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By Jun Ma, Lixin Hua, Yinxing Zhu, Guangyao Mao
| Dove Medical Press
Back to Journals » International Journal of Nanomedicine » Volume 19 Authors Ma J, Hua L, Zhu Y, Mao G, Fu C, Qin S Received 22 June 2024 Accepted for publication 21 October 2024 Published 3 November 2024 Volume 2024:19 Pages 11181—11194 DOI https://doi.org/10.2147/IJN.S483815 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Jie Huang Jun Ma,1,* Lixin Hua,2,* Yinxing Zhu,3 Guangyao Mao,4 Chunsheng...
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