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Yinyao Lin on Muck Rack

Yinyao Lin

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Inhibition of interaction between ROCK1 and Rubicon restores autophagy in endothelial cells and attenuates brain injury after prolonged ischemia

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By Yinyao Lin, Zexin Zhan, Mengyan Hu, Haiyan Li
| Wiley Online Library Verified
Abstract Abstract Acute ischemic stroke (AIS) induces cerebral endothelial cells death resulting in the breakdown of blood-brain barrier (BBB). Endothelial cells autophagy acts as a protective mechanism against cell death. Autophagy is activated in the very early stages of ischemic stroke and declines after prolonged ischemia. Previous studies have shown that Rubicon can inhibit autophagy.
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