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Yinyin Yang

As seen in: Nature, ACS Publications
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Articles

Targeting the PRMT5-CBX8 axis overcomes dual barriers of CD8⁺ T cell exclusion and tumor stemness for sensitizing TNBC to anti-PD-1 therapy

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By Congcong Chen, Yuheng Zhang, Chang Liu, Runkai Zhao, Kaiming Liu, Zhiqi Guo, Yinyin Yang, Cong Wang, Jiaxin Tian, Guo rui Chen, Liyan Jin, Xun Zhu, Danyang Zhou, Guoqin Jiang, Yanguan Guo
| Nature Verified
Abstract The efficacy of immune checkpoint blockade in triple-negative breast cancer (TNBC) is limited by poor CD8⁺ T cell infiltration. Here, we demonstrate that tumor-derived proprotein convertase subtilisin/kexin type 9 (PCSK9) drives CD8⁺ T cell exclusion, and we identify protein arginine methyltransferase 5 (PRMT5) as an important epigenetic regulator responsible for PCSK9 expression in TNBC.
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Correction to “Phosphorylation as an Effective Tool to Improve Stability and Reduce Toxicity of Antimicrobial Peptides”

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By Zufang Ba, Yu Wang, Yinyin Yang, Bingqian Ren
| ACS Publications
Journal of Medicinal Chemistry Cite this: J. Med. Chem. 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is available under these Terms of Use. Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.
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Phosphorylation as an Effective Tool to Improve Stability and Reduce Toxicity of Antimicrobial Peptides

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By Zufang Ba, Yu Wang, Bingqian Ren, Yinyin Yang
| dx.doi.org
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