Yishi Li

Abstract Zinc transporters regulate intracellular zinc homeostasis, but their role in acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) remains underexplored. Here, we show that the zinc transporter SLC39A1 is highly upregulated in alveolar type II (AT2) cells from male murine ALI models and patients with ARDS. AT2-specific Slc39a1 deletion or zinc chelation exacerbates lung injury, whereas overexpression or zinc supplementation attenuates it.

Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References , and . 2013. “The Purchasing Power Parity Hypothesis in the US–China Relationship: Fractional Intergration, Time Variation and Data Frequency.” International Journal of Finance and Economics 18, no. 1: 82–92. https://doi.org/10.1002/ijfe.461. , and . 2013.

2.3. Graphical Display of Network In the analysis, 31 nodes and 312 edges were obtained in the graphs, consisting of the entire network, with all these edges hiding the basic figures in the network structure. Hence, network graphs only denote the thickest edges, which is merely a visual choice. Statistics related to all the networks were computed using the full network. Following Bostanci and Yilmaz [16] and Demirer et al.