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Articles

Six1 haploinsufficiency is associated with activation of NF-κB and TNF-related transcriptional signatures in aging mice

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By Han Liu, Junjun Ma, Huanyu Yan, Yanglin Chen, Lihua Zhao, Xiyun Guo, Limin Lv, YIXI WANG, Linxin Cheng, Guang Yang, Yu An Zhang, Jinbo Yu, Xi Wang, Shuguang Duo, Xihe Li, Rongfeng Li, Tianxu Guo
| Nature Verified
Abstract The Six1 (SIX homeobox 1) gene is pivotal in renal and pulmonary development and differentiation. Its dysregulation is implicated in oncogenesis and tumor progression via enhancing cell proliferation and delaying senescence. However, whether or how it functions in the natural aging have not been investigated. To answer this question, we generated Six1 gene knockout mice using CRISPR-Cas9 technology. All Six1 biallelic knockout mice died at birth since the underdeveloped lungs.
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How educational inequality among rural residents relates to healthy lifestyle behaviors in later life: evidence from the Northern China lifestyle medicine cohort baseline

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By Yudong Miao, Jinxin Cui, Lei Yin, Zhanlei Shen, Dongfang Zhu, Jingbao Zhang, Jiajia Zhang, Xinran Li, YIXI WANG, Jiaxin Han, Jingming Wei, Clifford Silver Tarimo, Qiuping Zhao, Rongmei Liu, Qingyong Lu, Mingyue Zhen, Lingxiao Mou, Jingwei Qin, Nengguang Dai
| Nature Verified
Abstract Educational inequality affects health, but its link to healthy lifestyles among older adults in low-resource rural settings remains unclear. This study utilized baseline data from the Northern China Lifestyle Medicine Cohort (July 2023–January 2024). Adults aged 65 and older with hypertension or diabetes in the National Basic Public Health Service program were included. A composite Healthy Lifestyle Score (HLS, range 0–7) was constructed from seven behavioral indicators.
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Unraveling the Synergistic Mechanism of Ir Species with Various Electron Densities over an Ir/ZSM-5 Catalyst Enables High-Efficiency NO Reduction by CO

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By Huixian Liu, YIXI WANG, Wenqing Xu, Jun Yang
| dx.doi.org
RETURN TO ARTICLES ASAPPREVOccurrence, Fate, an...Occurrence, Fate, and Transport of Contaminants in Indoor Air and AtmosphereNEXT Huixian Liu CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China , Yixi Wang CAS Key Laboratory of Green Process and Engineering,...
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