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Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation
1 Introduction Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide and is characterized by the sequential accumulation of mutations.[1] Activating mutations in driver genes bestow adenomas with unlimited proliferative capacity, thereby instigating CRC.[2] To meet the bioenergetic and biosynthetic needs for uncontrolled growth during CRC initiation, cancer cells undergo metabolic reprogramming, particularly under hypoxic and hypovascular conditions, to acquire a...
Villin‐1 regulates ferroptosis in colorectal cancer progression
Conflict of interest The authors declare no conflict of interest. Supporting Information Filename Description febs17350-sup-0001-supinfo.pdfPDF document, 470 KB Fig. S1. Comparison of VIL1 mRNA expression in tumor and control tissues in (A) GSE128435; (B) GSE146889; (C) GSE20970; (D) GSE21815; and (E) GSE73360. Fig. S2. (A) mRNA expression of VIL1 in CRC cells (HCT116 and HT29) and human normal colonic epithelial cells (NCM460).
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