Yiying Mai
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Synergistic antitumor effect of HMGB2 targeting combined with MDM2 inhibitor in diffuse intrinsic pontine glioma therapy
Abstract Diffuse intrinsic pontine glioma (DIPG) is a brain malignancy in children with a dismal prognosis. The high mobility group box 2 (HMGB2) is a member of the HMGB family of chromatin-associated proteins, and is identified as a potential oncogene in various cancers. However, the effects of HMGB2 in DIPG remains unclear.
A framework for comparative analysis of human and mouse cortical neuron dendrites in corresponding brain regions
Abstract Cross-species comparisons of neuronal morphology can reveal evolutionary diversification of cortical organization, but they remain limited by scarce human reconstructions, uncertain regional correspondence and scale-dependent morphometrics. Here we introduce a region correspondence framework to compare single-neuron dendritic morphology between mouse and human cortex.
Quantitative analysis of effectiveness and associated factors of exercise on symptoms in osteoarthritis: a pharmacodynamic model-based meta-analysis
Abstract Objective This study aims to evaluate the time point and magnitude of peak effectiveness of exercise and the effects of various exercise modalities for osteoarthritis (OA) symptoms and to identify factors that significantly affect the effectiveness of exercise. Design Pharmacodynamic model-based meta-analysis (MBMA).
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