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Yiying Xu on Muck Rack

Yiying Xu

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Articles

Transcription factor ID2 prevents E proteins from enforcing a naïve T lymphocyte gene program during NK cell development

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By Erin C. Zook, Mihalis Verykokakis, Zhong-Yin Li, Yiying Xu
| Science Magazine Verified
The transcription factor ID2 is required for normal differentiation of all innate lymphoid cells, including natural killer (NK) cells. Zook et al. have characterized ID2-deficient NK cells and investigated how ID2 supports full maturation of NK cells into cytotoxic effectors. They found that ID2 limited chromatin accessibility at multiple lymphocyte-associated genes correlated with a naïve gene program, thereby enabling an effector gene program to take hold.
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