Yizhen Yin
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Intranasal administration of broad-spectrum macrocyclic peptide inhibitor protects against SARS-CoV-2 Omicron variants - Nature Communications
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to cause significant morbidity and mortality despite the end of its pandemic phase. The emergence of highly mutated SARS-CoV-2 variants of concern highlights the requirement of broad-spectrum antiviral countermeasures which possess both prophylactic and therapeutic efficacies. Here, we obtain a macrocyclic peptide, 6L3-3P11K, that effectively inhibits a wide range of SARS-CoV-2 variants and subvariants.
Recent Advances in Non‐Standard Macrocyclic Peptide Ligand Discovery using mRNA Display
Advancements in platform technologies have facilitated the production of libraries consisting of macrocyclic peptides composed of natural and non-canonical amino acids for more drug-like characteristics. Identification of macrocyclic peptide ligands against targets of interest can be accomplished using mRNA display.
Integrating the administrative spillover effect into the spatial governance system to revisit land development: A study in urban-rural fringe areas of Wuhan and neighboring cities, China
[1] Department of Land Management, Huazhong Agricultural University, Wuhan 430070, China [2] School of Management and Economics, Tianjin University, Tianjin 300072, China [3] College of Urban Economics and Public Administration, Capital University of Economics and Business, Beijing 100070, China [4] Research Institute of Land Development and Regional Economy, National Development and Reform Commission, Beijing 100032, China
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