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Yogy Simanjuntak on Muck Rack

Yogy Simanjuntak

As seen in: Nature
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Articles

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection - Nature Communications

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By Yogy Simanjuntak, Philippe Baltzinger, Catherine Schuster, Mathias Heikenwalder, Jane A. McKeating, Irwin Davidson, Ming-Lung Yu, Yujin Hoshida, Kazuaki Chayama, Joachim Lupberger, Atish Mukherji
| Nature Verified
Abstract Chronic liver disease and cancer are global health challenges. The role of the circadian clock as a regulator of liver physiology and disease is well established in rodents, however, the identity and epigenetic regulation of rhythmically expressed genes in human disease is less well studied. Here we unravel the rhythmic transcriptome and epigenome of human hepatocytes using male human liver chimeric mice.
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Benzenesulfonamide Derivatives as Calcium/Calmodulin-Dependent Protein Kinase Inhibitors and Antiviral Agents against Dengue and Zika Virus Infections

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By Yogy Simanjuntak, Wei-Chia Chen, Li-Wei Chu, Yueh-Hsin Ping
| American Chemical Society
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Med. Chem.
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Ebselen alleviates testicular pathology in mice with Zika virus infection and prevents its sexual transmission

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By Academia Sinica, Si-Yu Chen, Yogy Simanjuntak, Jian-Jong Liang, PLOS Pathogens
| PLOS
Despite the low case fatality, Zika virus (ZIKV) infection has been associated with microcephaly in infants and Guillain-Barré syndrome. Antiviral and vaccine developments against ZIKV are still ongoing; therefore, in the meantime, preventing the disease transmission is critical. Primarily transmitted by Aedes species mosquitoes, ZIKV also can be sexually transmitted. We used AG129 mice lacking interferon-α/β and -γ receptors to study the testicular pathogenesis and sexual transmission of ZIKV.
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