Yohei Kametani

Abstract Inorganic pyrophosphatases are essential metalloenzymes for phosphate metabolism. Bacterial Family II Inorganic pyrophosphatases utilize a trinuclear metal center and exhibit higher catalytic activity than binuclear counterparts. Here we show the mechanism underlying this enhanced hydrolytic efficiency in the enzyme from Shewanella sp. AS-11 using X-ray absorption spectroscopy, site-directed mutagenesis, and density functional theory calculations.

1 Introduction Electrochemical CO2 reduction (eCO2R), which provides valuable chemicals from CO2 and electricity, has attracted growing attention as a solution to the environmental and energy problems.[1, 2] As eCO2R catalysts, molecular systems, especially metal complexes,[3, 4] have been extensively studied along with inorganic[5-7] and inorganic/molecular hybrid[8] systems.

Graphical Abstract The Front Cover illustrates the catalytic transformation of carbon dioxide and epoxide to high-value-added carbonates by using a metal ion-modified photocatalyst under mild conditions, with solar light energy at ambient temperature and without the use of organic solvents. More information can be found in the Research Article by H. Shimakoshi and co-workers (DOI: 10.1002/chem.202501845).